*HELP with RNA seq data*
I have a question about Log(2) change 🤓I understand that this some measure of the change in transcript levels when comparing 2 treatments and is a ratio between the 2 treatment groups. What I cannot understand though is how to interpret the numbers. A log(2) fold change of more than 1 means enrichment (I think) and a negative log(2) fold enrichment is lower transcript levels (I think). Since log(2) fold change is a ratio, what does a log(2) change that is a positive value but less than 1 (+0 to 0.99) mean?
In an attempt to clarify my question: I have a table of log(2) fold changes that I am trying to interpret. I think a log(2) fold change of 2.2 = enrichment; a log(2) fold change of -0.33 is lower transcript levels (is this a correct interpretation?). What is a log(2) fold change of 0.67?
Any help is much appreciated
-
Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM -
Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...