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Related Articles Next-Generation DNA Sequencing Methods.
Annu Rev Genomics Hum Genet. 2008 Jun 19;
Authors: Mardis ER
Recent scientific discoveries that resulted from the application of next-generation DNA sequencing technologies highlight the striking impact of these massively parallel platforms on genetics. These new methods have expanded previously focused readouts from a variety of DNA preparation protocols to a genome-wide scale and have fine-tuned their resolution to single base precision. The sequencing of RNA also has transitioned and now includes full-length cDNA analyses, serial analysis of gene expression (SAGE)-based methods, and noncoding RNA discovery. Next-generation sequencing has also enabled novel applications such as the sequencing of ancient DNA samples, has substantially widened the scope of metagenomic analysis of environmentally derived samples. Taken together, an astounding potential exists for these technologies to bring enormous change in genetic and biological research and to enhance our fundamental biological knowledge. Expected final online publication date for the Annual Review of Genomics and Human Genetics Volume 9 is August 30, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
PMID: 18576944 [PubMed - as supplied by publisher]
More...
Related Articles Next-Generation DNA Sequencing Methods.
Annu Rev Genomics Hum Genet. 2008 Jun 19;
Authors: Mardis ER
Recent scientific discoveries that resulted from the application of next-generation DNA sequencing technologies highlight the striking impact of these massively parallel platforms on genetics. These new methods have expanded previously focused readouts from a variety of DNA preparation protocols to a genome-wide scale and have fine-tuned their resolution to single base precision. The sequencing of RNA also has transitioned and now includes full-length cDNA analyses, serial analysis of gene expression (SAGE)-based methods, and noncoding RNA discovery. Next-generation sequencing has also enabled novel applications such as the sequencing of ancient DNA samples, has substantially widened the scope of metagenomic analysis of environmentally derived samples. Taken together, an astounding potential exists for these technologies to bring enormous change in genetic and biological research and to enhance our fundamental biological knowledge. Expected final online publication date for the Annual Review of Genomics and Human Genetics Volume 9 is August 30, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
PMID: 18576944 [PubMed - as supplied by publisher]
More...