PubMed: A new strategy for genome assembly using short sequence reads and reduced rep

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A new strategy for genome assembly using short sequence reads and reduced representation libraries.

Genome Res. 2010 Feb;20(2):249-56

Authors: Young AL, Abaan HO, Zerbino D, Mullikin JC, Birney E, Margulies EH


We have developed a novel approach for using massively parallel short-read sequencing to generate fast and inexpensive de novo genomic assemblies comparable to those generated by capillary-based methods. The ultrashort (

[thomasvangurp]

Does anyone know if someone else has successfully applied this method? It sounds very promising for future whole genome sequencing efforts. Especially if one can multiplex the samples on the Hiseq