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A better way to map sequencing reads using existing read mapping tool

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  • A better way to map sequencing reads using existing read mapping tool

    Our group just published a paper on improving sequencing read mapping. We achieved this without inventing a new read alignment tool. The key is to customize the reference genome for each individual since mutation profile on many subjects are known a priori from previous array-based genotyping. Our software tool--RefEditor can work with any existing aligner such as BWA or bowtie.

    One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies
    http://journals.plos.org/ploscompbio...l.pcbi.1004448

    RefEditor is freely available at
    https://github.com/superyuan/refeditor

    Steve
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