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BINOCh: Binding Inference from Nucleosome Occupancy Changes.
Bioinformatics. 2011 May 5;
Authors: Meyer CA, He HH, Brown M, Liu XS
SUMMARY: Transcription factor binding events are frequently associated with a pattern of nucleosome occupancy changes in which nucleosomes flanking the binding site increase in occupancy while those in the vicinity of the binding site itself are displaced. Genome wide information on enhancer proximal nucleosome occupancy can be readily acquired using ChIP-seq targeting enhancer related histone modifications such as H3K4me2. Here we present a software package, BINOCh,that allows biologists to use such data to inferthe identity of key transcription factors that regulate the response of a cell to a stimulus or determine a program of differentiation. AVAILABILITY: The BINOChopen source Python package isfreely available at http://liulab.dfci.harvard.edu/BINOChunder the FreeBSDlicense. CONTACT: [email protected], [email protected].
PMID: 21551136 [PubMed - as supplied by publisher]
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BINOCh: Binding Inference from Nucleosome Occupancy Changes.
Bioinformatics. 2011 May 5;
Authors: Meyer CA, He HH, Brown M, Liu XS
SUMMARY: Transcription factor binding events are frequently associated with a pattern of nucleosome occupancy changes in which nucleosomes flanking the binding site increase in occupancy while those in the vicinity of the binding site itself are displaced. Genome wide information on enhancer proximal nucleosome occupancy can be readily acquired using ChIP-seq targeting enhancer related histone modifications such as H3K4me2. Here we present a software package, BINOCh,that allows biologists to use such data to inferthe identity of key transcription factors that regulate the response of a cell to a stimulus or determine a program of differentiation. AVAILABILITY: The BINOChopen source Python package isfreely available at http://liulab.dfci.harvard.edu/BINOChunder the FreeBSDlicense. CONTACT: [email protected], [email protected].
PMID: 21551136 [PubMed - as supplied by publisher]
More...