I think it was the third or fourth year of the original GSAC Hilton Head conference. We were as a community debating whether or not to begin a global effort to sequence all the genes from a single person. I think the word 'genome' had not quite been coined yet. At that meeting there was a panel discussion, which turned into a debate of sorts with the audience involved about whether or not such a project should be started. Wally Gilbert stood up and explained that we must, and further prophetically explained that new technologies would emerge that would drive the cost of sequencing dramatically down in a similar fashion as the semiconductor industry. Those were the days of manual slab gel sequencing. My recollection was that his argument sealed the debate, at least in my mind. The concept of sequencing a genome as inexpensively as we can now seemed so far fetched at the time. And yet, Wally foresaw all of this. I believe that session of the conference may have been recorded or filmed, and wonder if those film archives still exist. If so, who might have this pivotal and arguably treasured moment in history?
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by SEQadmin2
Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...-
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by SEQadmin2
Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...-
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