Have you ever read such report? seems I found some sequence error hotspots.
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Error "hotspots" exist for every technology I've looked at.
E.g.:- older Sanger ABIs (370 and 373) had the "AG-problem".
- 454 has the homopolymer problem. To be honest, Sanger sequencing and Solexa also have it ... but much less pronounced.
- for the Solexa projects I've analysed, I've seen strong bias after GGC.G, see also http://seqanswers.com/forums/showthread.php?t=1353
SOLiD I have no idea, I never analysed that data.
Regards,
B.
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07-08-2024, 03:19 PM -
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