Illumina's newest upgrades (a response to Life Tech?)

[ECO]

+1 krobison.

I will be very interested to see the per base pricing on the "Turbo" mode versus the "standard" longer run times. Clearly ILMN needs to get people stuffing more reagents into these big boxes...10-25 runs per year (as probably happens with most HiSeqs now) can't support a high growth business.

[krobison]

For clinical applications, the time for a HiSeq run is a significant impediment.

If the cost per genome doesn't go up, then upgrading machines is a route to higher throughput per machine (and sq ft of lab space) and could therefore be cost advantageous.

[GW_OK]

Double output with a turbo mode for impatient PI's?
Plus an incorporated cBot functionality?
Already considered, already budgeting for.

[turnersd]

Here's the announcement from Illumina about the HiSeq 2500 "genome-in-a-day" machine http://investor.illumina.com/phoenix...757&highlight=

[Richard Finney]

Illumina's stock price took a hit this morning but recovered quickly :

http://finance.yahoo.com/q/bc?s=ILMN+Basic+Chart&t=5d

Note the huge increase in volume and sharp recovery.

I have few ideas; but I"m guessing there's some skeptics out there.

Any fastqs available?

[GenoMax]

"More/faster" makes for a good headline but is this really a "must have" for people who have existing systems?

I just want to explore what people are thinking after reading these specs.

"-- Upgradable from HiSeq 2000 -- through a simple, field-based upgrade priced at $50,000"

For those of you who are already heavily invested in HiSeq 2000's is this upgrade something you will consider seriously?

[athos10025]

Illumina's new offerings

From

http://finance.yahoo.com/news/Illumina-Introduces-HiSeq-bw-684034008.html?x=0

The HiSeq 2500 offers:

Unprecedented Speed and Flexibility – two modes allow researchers to generate 120 gigabases (Gb) of data in 27 hours, or 600 Gb in a standard HiSeq run.
High Quality Data- system uses the proven SBS chemistry that has made both the HiSeq 2000 and the MiSeq systems the most accurate next-generation sequencers.

Expanding Applications – enables researchers to sequence a human genome or 20 exomes in a day, or 30 RNA sequencing samples in as little as five hours.
Industry Leading Simplicity and Ease-of-Use – integrated cluster generation process enables a simplified workflow similar the MiSeq platform.
Upgradable from HiSeq 2000 – through a simple, field-based upgrade priced at $50,000.

The Company also announced the following performance enhancements to the MiSeq personal sequencer:

Threefold Increase in Throughput – capable of generating up to 7 Gb per run, expanding the number of applications and increasing sample throughput.

Longer and More Reads – a new 500-cycle reagent kit supports 2 x 250 bp runs, generating over 15 million clusters per run and enabling more accurate small-genome assembly and small RNA sequencing projects.
Faster Run Times – Faster cycle times enable rapid turnaround applications, allowing researchers to perform microbial identification sequencing in as little as 2 ½ hours.

[ECO]

More specs from here:

The HiSeq 2500 offers:

-- Unprecedented Speed and Flexibility -- two modes allow researchers to generate 120 gigabases (Gb) of data in 27 hours, or 600 Gb in a standard HiSeq run.
-- High Quality Data- system uses the proven SBS chemistry that has made both the HiSeq 2000 and the MiSeq systems the most accurate next-generation sequencers.
-- Expanding Applications -- enables researchers to sequence a human genome or 20 exomes in a day, or 30 RNA sequencing samples in as little as five hours.
-- Industry Leading Simplicity and Ease-of-Use -- integrated cluster generation process enables a simplified workflow similar the MiSeq platform.
-- Upgradable from HiSeq 2000 -- through a simple, field-based upgrade priced at $50,000.

The Company also announced the following performance enhancements to the MiSeq personal sequencer:

-- Threefold Increase in Throughput -- capable of generating up to 7 Gb per run, expanding the number of applications and increasing sample throughput.
-- Longer and More Reads -- a new 500-cycle reagent kit supports 2 x 250 bp runs, generating over 15 million clusters per run and enabling more accurate small-genome assembly and small RNA sequencing projects.
-- Faster Run Times -- Faster cycle times enable rapid turnaround applications, allowing researchers to perform microbial identification sequencing in as little as 2 1/2 hours.

[GW_OK]

For those of you who haven't been monitoring the latest thread over in the Ion Torrent forum. From Twitter:
Illumina announces #HiSeq 2500: able to seq entire genome or 20 exomes in 24h. #JPM12 #GenomeInADay

Illumina introduces #MiSeq enhanced performance w/ 3-fold throughput increase (7 Gb), faster cycles & 250 bp PE reads. #JPM12


How exciting!


Edit:
@illumina is working on new chemistry. "chemistry B" which is their stab at single molecule detection. #JPM12

I wonder if this has something to do with this:

http://news.harvard.edu/gazette/story/2012/01/reading-life%E2%80%99s-building-blocks/