We have 10k pcr product to construct the pacbio library. The original and concentrate DNA look good on bioanalyzer, and the band is pure 10kb band. However, the library is smear from 3kb to 10kb. please refer to the attach file. Why the DNA degrade? We don't even use vortex to treat DNA. Does anyone have the experience like that?
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM