combinatorial histone methylation patterns

[LouDore]

There was a paper in the past few years that looked at dozens of distinct histone modifications (methylations & acetylations) in a mammalian cell type by ChIP-Seq, then defined some of the most common combinations and drew conclusions about what functions those specific combinations may be responsible for based on location relative to genes, etc...

I can't remember any more info about the paper, but I KNOW I read a paper like that and wasn't just dreaming...but I can't seem to find it anywhere among my papers or after an hour searching pubmed and google.

Does anybody know what I'm talking about? Can you point me to a reference if you think you know?

Thanks,
Lou

[ECO]

Moving to Epigenetics!

[kopi-o]

Perhaps one of the ChromaSig papers?

[ffinkernagel]

Was it
Wang et al, "Combinatorial patterns of histone acetylations and methylations in the human genome"

http://www.nature.com/ng/journal/v40/n7/full/ng.154.html

or perhaps
Cui et al, "Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation"
http://www.cell.com/cell-stem-cell/r...34590908005821

[paulbible]

I came across this paper last summer.
Christoph Bock and Thomas Lengauer "Computational epigenetics"
http://bioinformatics.oxfordjournals...4/1/1.abstract

[simonandrews]

It's not mammalian, but could you be thinking about the 'chromatin colors' paper in drosophila? It's worth reading even if this wasn't what you were remembering.

[LouDore]

Was looking through Ernst et al today from the recent issue of Nature and saw the chromatin state table in Fig 1b and knew I had finally found what I was searching for...

The style of the table was so similar to the image I had in my mind that I was searching for when I started this thread. Anyway, this led me to the Nature Biotechnology paper from Ernst & Kellis in Aug 2010 which is exactly what I've been looking for.

Thanks for all the suggestions, everybody -- all very interesting and I hadn't come across 1 or 2 of them during my extensive searching.