Do you guys have any idea which NGS platform is the most suitable for doing the whole genome rearrangement project ?
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Bioinformatics Intern.
Master program in Bioinformatics. -
Any paired-end or long read platform will be adequate.
Solexa, SOLiD and 454 will all work for this type of project, and you should consider how much you're planning to sequence and what resources are available to you to decide which to use.Mendelian Disorder: A blogshare of random useful information for general public consumption. [Blog]
Breakway: A Program to Identify Structural Variations in Genomic Data [Website] [Forum Post]
Projects: U87MG whole genome sequence [Website] [Paper] -
Also, if you're looking at structural variation ... a mate-paired library would be ideal.Nicolas Tremblay
Graduate Student
Cardiovascular Genetics - Andelfinger Lab
CHU Ste-Justine Research CenterComment
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NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification,...10-30-2026, 06:46 AM
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