Hello everyone,
I was asking myself if it is possible so adequately simulate (simple) inversions and (inter-chromosomal) translocations. Does anyone have experience with this?
Well there are some tools, that simulate (small) indels or approaches which implement known indels into a reference genome. But I never read if someone put effort into simultating inversions and especially translocations. I'd say this could also be useful for testing.
I know, that especially translocations can be a very complicated and complex process, involving other variations like deletions, insertions and inversions at the breakpoint. But would be great if someone had some experience with this or even knew an appropriate tool.
Thanks in advance!
Kind regards,
Christoph
I was asking myself if it is possible so adequately simulate (simple) inversions and (inter-chromosomal) translocations. Does anyone have experience with this?
Well there are some tools, that simulate (small) indels or approaches which implement known indels into a reference genome. But I never read if someone put effort into simultating inversions and especially translocations. I'd say this could also be useful for testing.
I know, that especially translocations can be a very complicated and complex process, involving other variations like deletions, insertions and inversions at the breakpoint. But would be great if someone had some experience with this or even knew an appropriate tool.
Thanks in advance!
Kind regards,
Christoph
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