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Dear all,
I wish to use the CONTRA software in order to detect CNV on WES data.
I must analyse a project consisting of 42 samples of male and female humans.
To analyze this project, I have first created a baseline with all samples and then I have compared each sample to the baseline.
However, with this method, all samples from male human have a lot of CNV (loss) on the chrX, by the fact that males have only one chrX.
So, I would to know what it is the best way to use CONTRA on such kind of dataset (with male and female humans) in order to avoid this phenomena?
Thank you in advance for your answer.
I wish to use the CONTRA software in order to detect CNV on WES data.
I must analyse a project consisting of 42 samples of male and female humans.
To analyze this project, I have first created a baseline with all samples and then I have compared each sample to the baseline.
However, with this method, all samples from male human have a lot of CNV (loss) on the chrX, by the fact that males have only one chrX.
So, I would to know what it is the best way to use CONTRA on such kind of dataset (with male and female humans) in order to avoid this phenomena?
Thank you in advance for your answer.