I am using Samtools v0.1.12a to query 1000 Genomes data. When using samtools tview to locations where STR repeats should occur, most of the repeats are the same for most of the samples even on very fast moving markers. Most of the 1000 Genomes literature seems to be around finding SNPs, so I haven't found anything on why the STR data is the way it is. Does anyone know why?
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM