Hi there!
I’ve read the paper by J. Bullard (Sandrine Dudoit’s group) about expression level and its relation with the read counts in RNA-Seq:
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments
The equation (1) in the paper provides the relation between expected read counts and expression levels. This model is linear and is a good representation of the relation. However, I was wondering if there is any other paper(s) that studied a non-linear model, especially exponential relations.
Any hint is appreciated!
I’ve read the paper by J. Bullard (Sandrine Dudoit’s group) about expression level and its relation with the read counts in RNA-Seq:
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments
The equation (1) in the paper provides the relation between expected read counts and expression levels. This model is linear and is a good representation of the relation. However, I was wondering if there is any other paper(s) that studied a non-linear model, especially exponential relations.
Any hint is appreciated!
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