Non-linear model for RNA-Seq (reads and expression levels)

[tldgID]

Hi there!

I’ve read the paper by J. Bullard (Sandrine Dudoit’s group) about expression level and its relation with the read counts in RNA-Seq:

Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

The equation (1) in the paper provides the relation between expected read counts and expression levels. This model is linear and is a good representation of the relation. However, I was wondering if there is any other paper(s) that studied a non-linear model, especially exponential relations.

Any hint is appreciated!

[nzhao]

Hello,

I have recently read a paper

http://www.ncbi.nlm.nih.gov/pubmed/21838806

which utilized Poisson regression to analyze count data.

Best