overdispersion and biological replicates

shilez

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Join Date: Jun 2010

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overdispersion and biological replicates

08-25-2011, 06:10 PM

Hi there,

I really appreciate the work of DESeq and EdgeR for taking the overdispersion into account for biological replicates. However assuming when analyzing tumor samples in a few cancer subgroups, do samples in the same subgroup count as "biological replicates" too? Particularly does the overdispersion model in DESeq statistically sound for a potential more variable samples within a subgroup?
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