Allelic imbalance and expression

kenosaki

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Join Date: May 2010

Posts: 27
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#1

Allelic imbalance and expression

08-08-2010, 11:15 PM

Hi,

Does anyone know the method or tools to find the region of allelic imbalance in RNA-Seq transcripts?

I read one paper
Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations.
showing the correlations of expression value, CNV and AI.

Does anyone know the similar papers or algorithm?

Thanks.
Ken
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townway

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Join Date: May 2009

Posts: 41
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#2

08-09-2010, 06:37 AM

There are a lot. check this out.

Science. 2010 Aug 6;329(5992):643-8. Epub 2010 Jul 8.
High-Resolution Analysis of Parent-of-Origin Allelic Expression in the Mouse Brain.

Gregg C, Zhang J, Weissbourd B, Luo S, Schroth GP, Haig D, Dulac C.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
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