Manipulating normal samples for CNV analysis

[vikasbansal]

Dear all,

I have exome sequence data for about 100 patients. I found some tools like VarScan, ExomeCNV etc for CNV analysis. But they all need normal individual data also. Now I managed to get 10 normal samples. My question is -> should I randomly select any 1 normal sample for CNV analysis or is there any way to use all these normal samples as 1 sample?

Any suggestions?

Thanks
Vikas