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  • newBioinfo
    Member
    • Mar 2012
    • 36

    #1

    RNA secondary structure alignment

    Hi All,
    Is there any aligner that can align RNA based on secondary structure.



    Thanks!!!
  • ppgardne
    Member
    • Oct 2010
    • 13

    #2
    There are a few. RNAforester is one. It's not the generally recommended approach.

    Comment

    • newBioinfo
      Member
      • Mar 2012
      • 36

      #3
      Thanks ppgarnde,
      Can Infernal in RDP databse can do this?

      Comment

      • ppgardne
        Member
        • Oct 2010
        • 13

        #4
        Infernal is great. It is very accurate and fast. It will align sequences to structures based upon sequence information and structure. It is designed primarily for the homology search problem.

        I thought you were trying to align two or more structures to each other.

        Comment

        • newBioinfo
          Member
          • Mar 2012
          • 36

          #5
          Originally posted by ppgardne View Post
          Infernal is great. It is very accurate and fast. It will align sequences to structures based upon sequence information and structure. It is designed primarily for the homology search problem.

          I thought you were trying to align two or more structures to each other.
          Thanks ppgardne,
          I have reads from sequencing and I want to align these to ribosomal database based on secondary structure. I have aligned based on sequence and want to see if aligning based on secondary structure gives anything different.

          Thanks!!!

          Comment

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