Why does UCSC genome browser NOT using spatial index?
UCSC genome browser uses binning strategy to retrieve genes more efficiently than simply creating a B-tree on the start and end coordinates. This certainly serves the purpose well because query ranges is not a strengthen of B-tree. But binning + B-tree basically provides a crude approximation to R-tree (using spatial index) that has already been implemented in MySQL. I'm wondering why is this spatial index not used in the first place? Is it because the spatial index is a relatively new feature that was not implemented in MySQL when the UCSC GB was developed? Just curious.
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM
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