UCSC genome browser uses binning strategy to retrieve genes more efficiently than simply creating a B-tree on the start and end coordinates. This certainly serves the purpose well because query ranges is not a strengthen of B-tree. But binning + B-tree basically provides a crude approximation to R-tree (using spatial index) that has already been implemented in MySQL. I'm wondering why is this spatial index not used in the first place? Is it because the spatial index is a relatively new feature that was not implemented in MySQL when the UCSC GB was developed? Just curious.
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by SEQadmin2
Data variability is still an issue in sequencing technologies despite the advances in reproducibility and accuracy of these platforms. But the problem does not originate in the sequencing itself, but in the previous steps, before the sample reaches the sequencer.
The first step is collection, followed by preservation and sample preparation for analysis. Most scientists overlook those steps, but not being careful might just be skewing the experiment’s results.
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Channel: Articles
06-02-2026, 10:05 AM -
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by SEQadmin2
With the launch of new single-cell sequencing platforms in 2026, the field stands at an exciting inflection point. This article surveys the most impactful advances in the field and discusses how they’re reshaping research in cancer, immunology, and beyond.
Introduction
Single-cell sequencing technologies have undergone remarkable advances over the past decade, transitioning from low-throughput experimental approaches to highly scalable platforms capable of...-
Channel: Articles
05-22-2026, 06:42 AM -
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