I've sequenced some HLA and KIR genes by using Agilent SureSelect target enrichment kit, together with other target regions. The sequencing platform was Illumina paired-end using HiSeq. Any idea is it possible for me to do HLA genotyping from the aligned reads? Any software or method to perform the genotyping? Thanks
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You might be interested in Omixon for this :
This recent paper might also be of interest:
Last edited by Bukowski; 06-03-2014, 11:26 AM.
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM
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