The 1000 genomes research article(http://www.nature.com/nature/journal...ture11632.html) studies f2 variants. They refer to these as "Variants present twice across the entire sample (referred to as f2 variants), typically the most recent of informative mutations, are found within the same population in 53% of cases". Can anybody please elaborate/explain as to what are these f2 variants? I am confused as to are these variants - ones with the variant allele is present on both the chromosomes at the same locus(Homozygous alternate) or something else.
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NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification,...10-30-2026, 06:46 AM
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