ti/tv ratio and false positive SNP rate

[yi2004]

I learned that estimated false positive SNP rate=1- (observed_ti/tv_ratio-0.5)/(expected_ti/tv_ratio-0.5). In one of our re-sequencing data, the observed ti/tv ratio for coding region is 3.0 (while expected ti/tv ratio for exome is 2.8). But false positive rate can not be negative...

[Pepe]

What do ti and tv stand for?

[nilshomer]

What do ti and tv stand for?

Transition and transversion mutation rates.

[yi2004]

Does anybody know why the false positive SNP rate is estimated as
1- (observed_ti/tv_ratio-0.5)/(expected_ti/tv_ratio -0.5)?
Any reference to this is much appreciated.

[nilshomer]

Does anybody know why the false positive SNP rate is estimated as
1- (observed_ti/tv_ratio-0.5)/(expected_ti/tv_ratio -0.5)?
Any reference to this is much appreciated.

I used google:

http://www.megasoftware.net/WebHelp/glossary/rh_transition_transversion_ratio_r.htm

[yi2004]

I used google:
http://www.megasoftware.net/WebHelp/...on_ratio_r.htm

Thanks Nilshomer! I will have a look at the website you pointed at, and hope I can figure out the answer to my question...