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  • lsantome
    started a topic linkage analysis in targeted NGS data

    linkage analysis in targeted NGS data

    hi all,

    tipically the aim of linkage analysis in human disease is to detect candiate genes based upon cosegregation of SNP markers and the familial phenotype.

    but, what if I have the candidate gene (and mutation) and I want to quantify its association with the trait? can I use the same approach?

    I'm working with targeted NGS data (gene pannels) and I want to demonstrate the association between a candidate variant and a phenotype not previously reported.

    Any suggestion is welcome

    Thank you in advance!

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