hi all,
tipically the aim of linkage analysis in human disease is to detect candiate genes based upon cosegregation of SNP markers and the familial phenotype.
but, what if I have the candidate gene (and mutation) and I want to quantify its association with the trait? can I use the same approach?
I'm working with targeted NGS data (gene pannels) and I want to demonstrate the association between a candidate variant and a phenotype not previously reported.
Any suggestion is welcome
Thank you in advance!
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