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  • lsantome
    started a topic linkage analysis in targeted NGS data

    linkage analysis in targeted NGS data

    hi all,

    tipically the aim of linkage analysis in human disease is to detect candiate genes based upon cosegregation of SNP markers and the familial phenotype.

    but, what if I have the candidate gene (and mutation) and I want to quantify its association with the trait? can I use the same approach?

    I'm working with targeted NGS data (gene pannels) and I want to demonstrate the association between a candidate variant and a phenotype not previously reported.

    Any suggestion is welcome

    Thank you in advance!

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  • seqadmin
    Multiomics Techniques Advancing Disease Research
    by seqadmin


    New and advanced multiomics tools and technologies have opened new avenues of research and markedly enhanced various disciplines such as disease research and precision medicine1. The practice of merging diverse data from various ‘omes increasingly provides a more holistic understanding of biological systems. As Maddison Masaeli, Co-Founder and CEO at Deepcell, aptly noted, “You can't explain biology in its complex form with one modality.”

    A major leap in the field has
    ...
    02-08-2024, 06:33 AM

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