Identifying paralogs for a whole genome
I have an e. coli genome and I want to know which genes are paralogs so I can investigate how RNA-seq reads are mapping to multiple positions. What I would like to do is get a full list of paralogs within my e.coli genome. I could blast the genome against itself and write some scripts to sort and select potential paralogs, but it seems like a problem that many people have likely encountered in the past and I don't want to reinvent the wheel if I don't have to. Is there a tool out there that can do this sort of thing already? Thanks very much!
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
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