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.rod files with annotation for snps - anyone know what these look like?
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> head dbsnp_130_hg18.rod
585 chr1 259 260 rs72477211 0 + C C A/G genomic single unknown 0 0 unknown exact 3
585 chr1 491 492 rs55998931 0 + C C C/T genomic single unknown 0 0 unknown exact 1
585 chr1 518 519 rs62636508 0 + G G C/G genomic single unknown 0 0 unknown exact 1
585 chr1 582 583 rs58108140 0 + G G A/G genomic single unknown 0 0 unknown exact 1
585 chr1 800 801 rs28853987 0 + G G A/G genomic single unknown 0 0 unknown exact 1
585 chr1 876 877 rs28484712 0 + G G A/G genomic single unknown 0 0 unknown exact 1
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Genomics studies in neuroscience face a special challenge due to the brain’s complexity and scarcity of samples. Mapping changes in cell type and state using conventional next-generation sequencing methods remains challenging. Advances in technologies like single-cell sequencing, spatial transcriptomics, and long-read sequencing have opened the door to deeper studies of the brain and diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and schizophrenia.
...07-09-2026, 11:10 AM -
Cancer survival rates have significantly increased in the last few decades in the United States, reaching a combined 70% 5-year survival rate by 2021. Behind this number, there are years of research to find new therapies, drug targets, and early detection methods. But there is one core challenge that keeps slowing down these advances, and it’s about drug resistance.
There is no single reason why many patients don’t respond to treatment as expected. Cancer is...07-08-2026, 05:17 AM -
Love this - good data definitely starts from good input, and poor input can only give relatively poor data. I particularly like the mention of Nanodrop/absorbance based methods for quantification. It's such a toss up if you'll get an accurate reading or what amounts to a randomly generated number, and a lot of library/sequencing related issues can be traced back to poor quant.07-01-2026, 11:43 AM
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