.rod files with annotation for snps - anyone know what these look like?
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> head dbsnp_130_hg18.rod
585 chr1 259 260 rs72477211 0 + C C A/G genomic single unknown 0 0 unknown exact 3
585 chr1 491 492 rs55998931 0 + C C C/T genomic single unknown 0 0 unknown exact 1
585 chr1 518 519 rs62636508 0 + G G C/G genomic single unknown 0 0 unknown exact 1
585 chr1 582 583 rs58108140 0 + G G A/G genomic single unknown 0 0 unknown exact 1
585 chr1 800 801 rs28853987 0 + G G A/G genomic single unknown 0 0 unknown exact 1
585 chr1 876 877 rs28484712 0 + G G A/G genomic single unknown 0 0 unknown exact 1
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM
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