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Discussion of next-gen sequencing related bioinformatics: resources, algorithms, open source efforts, etc

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Started by laura, 05-09-2011, 04:42 AM
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Started by sci_guy, 01-23-2008, 11:19 PM
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Started by asebastian, 03-31-2013, 08:53 PM
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Started by polijana, 03-31-2013, 01:51 PM
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Started by NGS_New_User, 03-31-2013, 01:35 PM
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Started by BioSlayer, 03-31-2013, 10:39 AM
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Started by Palgrave, 03-31-2013, 08:58 AM
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Started by Trudy, 02-07-2013, 08:48 AM
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  • SEQadmin2
    New Genomics Technologies Take Aim at Long-Standing Limits
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    Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.

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    The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.

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    CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).

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