Optimal bioinformatics computer configuration (budget 2500$)

[AcoBetalow]

Hello,

After setting up sequencing platform in our lab, we are looking for computer to do primary analysis on retrieved data. It would be very helpful, if anybody could lend any advice on best buy for stable configuration for this kind of work.

I have three sample configurations:

1.
X10SRL-F motherboard
CSE-732D4-500B chassis
CPU: 1x INTEL XEON E5-2620V3 + SNK
RAM: 4x 8GB DDR4 2133 ECC REGISTERED
HDD: 1x 2TB SATA3 ENTERPRISE
SSD: 1x 128GB SATA3

2. HP
F5W13AV HP Z440 Workstation
HP Z440 700W 90Percent Efficient Chassis
HP Z440 Country Kit
128GB SATA 1st SSD
2TB 7200 RPM SATA 2nd HDD
Intel Xeon E5-2630v3 2.4 20M 1866 8C CPU
32GB DDR4-2133 (4x8GB) RegRAM
HP Processor Air Cooling Kit

3. Supermicro
1x SUPERMICRO SuperChassis 743TQ-1200B-SQ
4x SUPERMICRO MEM-DR480L-CL01-ER21 8GB PC4-17000 DDR4 ECC registered
1x WD WD30EZRX 3TB 64M/S600 GreenPower
1x SAMSUNG 850 PRO series 128GB 25/S600
1x INTEL Xeon E5-2620 v3 2.4GHz 15MB 6C/12T
1x SUPERMICRO X10SRA~367,63 €

In terms of HP vs Supermicro, does anyone recommend one over the other?

Any help would be much appreciated, than you.

Greetings

[Zapages]

What will the purpose of this computer? Pre-processing?/Assembly?/Down stream analysis (Differential expression)?/BLASTX?

Will it be used for trimming raw reads/pre-processing the data/Cleaning up the data for contamination/etc?

Then do the assembly online via Galaxy/Iplant Collaborative/XSEDE?

I would go with as much ram as possible for down stream stuff.

Now if you are doing BLASTX or anything of that like. Then go with as many CPUs/Threads as possible.

I would recommend looking into this: http://www.thinkmate.com/system/vsx-r5-760

We bought one and we were able to get a real nice Academic discount.

All the best,

Zain

[AcoBetalow]

Thank you for reply Zapages, it has been very helpfull.

All the best,

Aleksander

[sarvidsson]

If it is an alternative, I'd try to get a refurbished server/workstation with more RAM (at least 96 GB, 48 GB would be an absolute minimum - with 32 GB you'd be severely limited for most analyses). I wouldn't go below 8 real cores (16 with hyperthreading), 12 would be better.
On eBay you can get used/refurbished Dell R610 or HP Z800 for a low price, which you could fit more RAM and as much disk you need.