Hi all, just wondering what the current state-of-play is with regards to clinical diagnostics labs, whether in the UK, European, or US context. Are small gene panels still the go-to? Or are more labs embracing whole-exome sequencing? Are any using full whole genome sequencing?
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In US, FDA has approved the following tests. All other uses are in research settings.
Last edited by GenoMax; 12-11-2018, 08:47 AM.
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM
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