I am new to the forum and need some initial recommendations. I will be receiving a data set from exome sequencing on an Illumina GA. What will be the best software to use for this initial data analysis...consider that I am new to NextGen sequencing. Thanks. and email to [email protected] would be appreciated if you have a great recommendation. I am understand that I should be able to upload shareware to do this.
-
-
search exome / capture sequencing
--
bioinfosm -
What questions are you trying to ask? What level of expertise do you have?
Most of the shareware is going to demand a high level of bioinformatics expertise & a bit of patience to use correctly. There are some integrated systems out there (such as Galaxy) which I have not tried and can't comment on how hard they are to install or use. The software wiki here should have a lot of fodder for you to graze on to identify packages that might suit your needs.
If you don't have the time, patience or expertise to muck around with these, you might want to consider forking out $$$ (or pounds or euros or whatever) for one of the commercial packages. They will tend to be very polished.Comment
-
CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM -
Proteomics platforms are evolving rapidly, with advances in mass spectrometry and affinity-based approaches expanding what researchers can detect and at what scale. As the field moves toward deeper proteome coverage and clinical applications, scientists face an increasingly complex landscape of tools. This article will explore how researchers are navigating these choices to find the right platform for their work.
The systematic characterization of the human proteome has...07-20-2026, 11:48 AM -
Genomics studies in neuroscience face a special challenge due to the brain’s complexity and scarcity of samples. Mapping changes in cell type and state using conventional next-generation sequencing methods remains challenging. Advances in technologies like single-cell sequencing, spatial transcriptomics, and long-read sequencing have opened the door to deeper studies of the brain and diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and schizophrenia.
...07-09-2026, 11:10 AM
Comment