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How to combine data from Human Methylation 27 and 450 platforms?
I am studying the Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) data set of TCGA. The DNA methylation datatype has 200 samples from Human Methylation 27 platform and 300 samples from Human Methylation 450 platform. These two platforms have methylation beta values for a common set of 25,978 CpG sites. Can I simply combine the samples from the two platforms using only the common set of 25,978 features?
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Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...
