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How to combine data from Human Methylation 27 and 450 platforms?
I am studying the Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) data set of TCGA. The DNA methylation datatype has 200 samples from Human Methylation 27 platform and 300 samples from Human Methylation 450 platform. These two platforms have methylation beta values for a common set of 25,978 CpG sites. Can I simply combine the samples from the two platforms using only the common set of 25,978 features?
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The human gut contains trillions of microorganisms that impact digestion, immune functions, and overall health1. Despite major breakthroughs, we’re only beginning to understand the full extent of the microbiome’s influence on health and disease. Advances in next-generation sequencing and spatial biology have opened new windows into this complex environment, yet many questions remain. This article highlights two recent studies exploring how diet influences microbial...02-24-2025, 06:31 AM