Seqanswers Leaderboard Ad

Collapse

Announcement

Collapse
No announcement yet.
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Genome-Wide Association Study Identifies Genetic Links to Smoking and Drinking

    A recent publication in Nature describes the results of a genome-wide association study (GWAS) that investigated genes, groups of genes, and variants associated with smoking and drinking. The study encompassed a total of 3,383,199 individuals and four major clines of global ancestry.

    The researchers identified 3,823 associated variants (from 2,143 loci) with behaviors of smoking or drinking. Notable results include 39 variants associated with the age individuals began smoking, 243 with cigarettes per day, 206 with smoking cessation (former smokers), and 849 with the number of alcoholic drinks per week. The data used in this study was taken from genome-wide arrays, along with some additional data from deep whole-genome sequencing.

    Despite the study's success, the results were limited by the diversity of the participants. In particular, the polygenic risk scores specific to individuals in the European ancestry group were poor predictors among the other ancestry groups. Although multiple ancestry groups were involved in this study, only 21% were of non-European descent, and several ancestry groups were excluded.

    The authors note these shortcomings and explain that future studies will need to include more genetic diversity to increase our understanding of genetics and behavior.

    Read the original journal article here.

Latest Articles

Collapse

  • seqadmin
    Exploring the Dynamics of the Tumor Microenvironment
    by seqadmin




    The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...
    07-08-2024, 03:19 PM
  • seqadmin
    Exploring Human Diversity Through Large-Scale Omics
    by seqadmin


    In 2003, researchers from the Human Genome Project (HGP) announced the most comprehensive genome to date1. Although the genome wasn’t fully completed until nearly 20 years later2, numerous large-scale projects, such as the International HapMap Project and 1000 Genomes Project, continued the HGP's work, capturing extensive variation and genomic diversity within humans. Recently, newer initiatives have significantly increased in scale and expanded beyond genomics, offering a more detailed...
    06-25-2024, 06:43 AM

ad_right_rmr

Collapse

News

Collapse

Topics Statistics Last Post
Started by seqadmin, 07-10-2024, 07:30 AM
0 responses
25 views
0 likes
Last Post seqadmin  
Started by seqadmin, 07-03-2024, 09:45 AM
0 responses
201 views
0 likes
Last Post seqadmin  
Started by seqadmin, 07-03-2024, 08:54 AM
0 responses
211 views
0 likes
Last Post seqadmin  
Started by seqadmin, 07-02-2024, 03:00 PM
0 responses
193 views
0 likes
Last Post seqadmin  
Working...
X