An interesting paper integrating Nanopores with optical detection rather than current sensing.
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Well, even ONT took almost 10 years to go from a research paper to a beta device, I think it is too premature to say whether this new tech will amount to anything interesting for now. -
The fine prints of this paper mentioned that this tech is already licensed to ONT. So this is not going to be a competitor of ONT.
If the current minion can be scaled to output 40Gb per box in the near future as ONT claimed, I don't see any big need for even higher throughput in the near future for this tech (or perhaps this tech is the secret behind the 40Gb output?). It is more important to improve the read accuracy to be on par with PacBio IMHO.Comment
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It may not affect ONT, but people (specially graduate students) who put their resources developing software for current ONT platform will be disappointed once they switch to optical detection.Comment
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NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification, detection...Today, 06:46 AM -
Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM
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