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An interesting paper integrating Nanopores with optical detection rather than current sensing.
http://www.nature.com/nnano/journal/...189.html#close
http://www.nature.com/nnano/journal/...189.html#close
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Well, even ONT took almost 10 years to go from a research paper to a beta device, I think it is too premature to say whether this new tech will amount to anything interesting for now. -
The fine prints of this paper mentioned that this tech is already licensed to ONT. So this is not going to be a competitor of ONT.
If the current minion can be scaled to output 40Gb per box in the near future as ONT claimed, I don't see any big need for even higher throughput in the near future for this tech (or perhaps this tech is the secret behind the 40Gb output?). It is more important to improve the read accuracy to be on par with PacBio IMHO.Comment
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It may not affect ONT, but people (specially graduate students) who put their resources developing software for current ONT platform will be disappointed once they switch to optical detection.Comment
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Differential Expression and Data Visualization: Recommended Tools for Next-Level Sequencing Analysis
After covering QC and alignment tools in the first segment and variant analysis and genome assembly in the second segment, we’re wrapping up with a discussion about tools for differential gene expression analysis and data visualization. In this article, we include recommendations from the following experts: Dr. Mark Ziemann, Senior Lecturer in Biotechnology and Bioinformatics, Deakin University; Dr. Medhat Mahmoud Postdoctoral Research Fellow at Baylor College of Medicine;...05-23-2023, 12:26 PM -
Continuing from our previous article, we share variant analysis and genome assembly tools recommended by our experts Dr. Medhat Mahmoud, Postdoctoral Research Fellow at Baylor College of Medicine, and Dr. Ming "Tommy" Tang, Director of Computational Biology at Immunitas and author of From Cell Line to Command Line.
Variant detection and analysis tools
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With new tools and computational resources being released regularly, it can be hard to determine which are best suited for the analysis process and which older tools continue to be maintained. In an effort to assist the sequencing community, we interviewed three highly skilled bioinformaticians about their recommended tools for several important analysis applications.
Quality control and preprocessing tools
“Garbage in, garbage out” is a popular...05-16-2023, 10:11 AM
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