It weighs a ton and takes up half a room. Why? Any engineers here that knows what's going on inside?
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among other things, laser & optics, filter, cooling for the reagents and the entire interior, a liquid handling robot, an overengineered air table that runs on nitrogen - which was not really needed. -
"..an overengineered air table that runs on nitrogen - which was not really needed" please elaborate
I look at the RSII and a ONT minion and they (skipping some details) pretty much do the same thing (produce long reads). Yet the one requires concrete reinforced floors and the other can be held in your hand. Just find it astounding the difference in scale.Comment
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One of them is an optical platform doing laser based detection of nanometre scale wells, and the other ... isn't. You can't 'skip the details' here, the details are the reasonOriginally posted by BioinformaticsBro View Post"..an overengineered air table that runs on nitrogen - which was not really needed" please elaborate
I look at the RSII and a ONT minion and they (skipping some details) pretty much do the same thing (produce long reads). Yet the one requires concrete reinforced floors and the other can be held in your hand. Just find it astounding the difference in scale.
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PacBio captures videos from single fluorescent molecules that are in a specific location only for milliseconds. Thus, they are trying to avoid any vibrations.Comment
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NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification, detection...Today, 06:46 AM -
Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM
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