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  • Improving the Sensitivity of Gene Fusion Detection from Archer® FusionPlex® Panels

    Recent studies point to promising new therapeutic options that can be applied in the presence of certain gene fusion events (such as NTRK gene fusions). Diagnostic labs can use RNA sequencing to detect such fusion events. The source material (e.g. tumor tissue) has to be prepared for sequencing using custom-made assays or using commercial assays such as Archer® FusionPlex®.


    Given that recently a new module for detecting fusion events was introduced to the Seamless NGS software platform, the developers were interested in how sensitive their approach is on existing data. Find out how the software platform performed: https://www.ecseq.com/blog/2020/Impr...ionPlex-Panels

    ecSeq Bioinformatics is Europe’s leading provider of hands-on bioinformatics workshops and professional data analysis in the field of Next-Generation Sequencing (NGS).

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  • seqadmin
    Essential Discoveries and Tools in Epitranscriptomics
    by seqadmin


    The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist on Modified Bases...
    Yesterday, 07:01 AM
  • seqadmin
    Current Approaches to Protein Sequencing
    by seqadmin


    Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...
    04-04-2024, 04:25 PM

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