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  • Laruo
    Member
    • Feb 2012
    • 13
    #1

    WGA for whole genome sequencing

    Hi,

    I'm thinking about a whole genome resequencing experiment for the identification of selection signatures. I will perform a WGA because we have a very low DNA quantity. I have read that SNP calling is very affected, specially in those regions with an insufficient coverage. So, I wonder which would be an appropiate coverage for an amplified sample...maybe the double of that of the unamplified one?

    Could anyone help me?

    Thanks!
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