How are folks sorting SNPs and indels into different classes based on their effect on coding sequence? Synonymous/ nonsynonymous/ changes to splice junctions, hits to exons/ introns/ promoters, etc? Any useful software out there?
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you can use SIFT if the SNPs are in the coding sequence of human genome. -
See this thread: http://seqanswers.com/forums/showthr...?t=6576&page=2Mendelian Disorder: A blogshare of random useful information for general public consumption. [Blog]
Breakway: A Program to Identify Structural Variations in Genomic Data [Website] [Forum Post]
Projects: U87MG whole genome sequence [Website] [Paper]Comment
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
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