How are folks sorting SNPs and indels into different classes based on their effect on coding sequence? Synonymous/ nonsynonymous/ changes to splice junctions, hits to exons/ introns/ promoters, etc? Any useful software out there?
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See this thread: http://seqanswers.com/forums/showthr...?t=6576&page=2Mendelian Disorder: A blogshare of random useful information for general public consumption. [Blog]
Breakway: A Program to Identify Structural Variations in Genomic Data [Website] [Forum Post]
Projects: U87MG whole genome sequence [Website] [Paper]
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The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.
This convergence of genetics, immunology, and computation...-
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