I have tried zorro on a genome of 450 MBp and I advise you not to try this. It is far too slow and basically unusable on a genome of this size.
I work on a project together with the developers of GAM and although nothing is public yet (and I am not sure when it will be) I have been testing an updated version designed to handle NGS assemblies and the results are excellent and the speed is also great. I will talk to the developer to ask when a public release could be possible.
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM -
Proteomics platforms are evolving rapidly, with advances in mass spectrometry and affinity-based approaches expanding what researchers can detect and at what scale. As the field moves toward deeper proteome coverage and clinical applications, scientists face an increasingly complex landscape of tools. This article will explore how researchers are navigating these choices to find the right platform for their work.
The systematic characterization of the human proteome has...07-20-2026, 11:48 AM
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