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denovo assembly
explanation about denovo asembly
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Assembling short reads to create full-length sequences . de-novo assemblies are orders of magnitude slower and more memory intensive than mapping assemblies. -
de novo is Latin, basically meaning "from new". So a de novo assembly is without knowing anything about the answer - compared to a reference guided assembly where you have a simple genome for guidance.Comment
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I love that such an incomplete question (phrase) got two thoughtful responses.Comment
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His/her ISP may be charging by the word to access the internet
Three posts (so far) by that user have less than 5 words each.
Originally posted by mgogol View PostComment
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Ha ha, good call.
On biostars, somebody would have deleted or closed it. I suppose there's a place for both approaches.Comment
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Genomics studies in neuroscience face a special challenge due to the brain’s complexity and scarcity of samples. Mapping changes in cell type and state using conventional next-generation sequencing methods remains challenging. Advances in technologies like single-cell sequencing, spatial transcriptomics, and long-read sequencing have opened the door to deeper studies of the brain and diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and schizophrenia.
...07-09-2026, 11:10 AM -
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There is no single reason why many patients don’t respond to treatment as expected. Cancer is...07-08-2026, 05:17 AM -
Love this - good data definitely starts from good input, and poor input can only give relatively poor data. I particularly like the mention of Nanodrop/absorbance based methods for quantification. It's such a toss up if you'll get an accurate reading or what amounts to a randomly generated number, and a lot of library/sequencing related issues can be traced back to poor quant.07-01-2026, 11:43 AM
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