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Kind of a beginner question here which is not specific to any particular organism. To train GlimmerHMM you need a file with the genes, and a file with the coordinates of the exons within those genes. The genes are downloadable from NCBI, but I am wondering how you get the exon coordinates. Are they also downloadable from NCBI? I feel like they should be, otherwise they wouldn't have the genes available if they didn't have some idea of the intron-exon boundaries within the genes. Or is the availability of the exon information dependent on the degree of annotation of the organism?
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Cancer survival rates have significantly increased in the last few decades in the United States, reaching a combined 70% 5-year survival rate by 2021. Behind this number, there are years of research to find new therapies, drug targets, and early detection methods. But there is one core challenge that keeps slowing down these advances, and it’s about drug resistance.
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