Tweet
Hi,
Does anybody know some tool to correct genome annotations?
Thanks in advance!
Does anybody know some tool to correct genome annotations?
Thanks in advance!
-
Last edited by diego diaz; 04-14-2015, 08:53 AM. -
It depends on what you want to do, are you preparing a genome submission yourself, or want to submit changes to an NCBI annotated genome? Or just clean up your own copy for internal use?Scott Monsma
Sr Scientist at Lucigen -
We want to clean up the annotation. Some genes are shown as more than one due to frameshifts generating stop codons. Frameshift seem to occur because homopolimersComment
-
Are the frameshifts just due to sequence errors? Or actually occur biologically?
NCBI's submission tools might be able to help you find the annotations that have the problem, but they're a bit of a pain to work with. You would need to convert your annotations list to their 5 column table format, and then use tbl2asn to validate the features listed in the table.Scott Monsma
Sr Scientist at LucigenComment
-
-
During the COVID-19 pandemic, scientists observed that while some individuals experienced severe illness when infected with SARS-CoV-2, others were barely affected. These disparities left researchers and clinicians wondering what causes the wide variations in response to viral infections and what role genetics plays.
Jean-Laurent Casanova, M.D., Ph.D., Professor at Rockefeller University, is a leading expert in this crossover between genetics and infectious...09-09-2024, 10:59 AM -
The first FDA-approved CRISPR-based therapy marked the transition of therapeutic gene editing from a dream to reality1. CRISPR technologies have streamlined gene editing, and CRISPR screens have become an important approach for identifying genes involved in disease processes2. This technique introduces targeted mutations across numerous genes, enabling large-scale identification of gene functions, interactions, and pathways3. Identifying the full range...08-27-2024, 04:44 AM
Comment