hi all,
tipically the aim of linkage analysis in human disease is to detect candiate genes based upon cosegregation of SNP markers and the familial phenotype.
but, what if I have the candidate gene (and mutation) and I want to quantify its association with the trait? can I use the same approach?
I'm working with targeted NGS data (gene pannels) and I want to demonstrate the association between a candidate variant and a phenotype not previously reported.
Any suggestion is welcome
Thank you in advance!
tipically the aim of linkage analysis in human disease is to detect candiate genes based upon cosegregation of SNP markers and the familial phenotype.
but, what if I have the candidate gene (and mutation) and I want to quantify its association with the trait? can I use the same approach?
I'm working with targeted NGS data (gene pannels) and I want to demonstrate the association between a candidate variant and a phenotype not previously reported.
Any suggestion is welcome
Thank you in advance!