Best RNA-Seq aligner: A comparison of mapping tools

[ecSeq Bioinformatics]

RNA-Seq has replaced microarrays for many applications in the area of biomarker discovery. The prices have been fallen substantially in recent years. The sequence data allows to extract more information than gene expression only. And there is no requirement that a reference genome must exist. However, the analysis of the resulting data is much more challenging and requires more ressources than other approaches.

So, the question is: How to choose between the available analysis tools? read more ...