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  • winsettz
    replied
    Originally posted by tir_al View Post
    I tried it on 75bp, cca 80 mil. reads, pair end bam file. And it crammed 3.6 GB file into a 257MB archive.
    Sounds like a promising way to store genomic data in the long run if indexed to hg19?

    Leave a comment:


  • tir_al
    replied
    I tried it on 75bp, cca 80 mil. reads, pair end bam file. And it crammed 3.6 GB file into a 257MB archive.

    Leave a comment:


  • winsettz
    replied
    tir_al,

    What is the compression ratio? Curious to see before I take a dive with my own data.

    Leave a comment:


  • tir_al
    replied
    Tnx for the prompt answer!

    I just tried cram today. The compression ratio is extremely impressive, but it's a too slow for my needs.

    Leave a comment:


  • GenoMax
    replied
    CRAM is reference based compression so may or may not be of interest for you. http://www.ebi.ac.uk/ena/about/cram_toolkit/

    Leave a comment:


  • tir_al
    started a topic FastQ/BAM compression

    FastQ/BAM compression

    Does anybody know of a more recent comparison of algorithms for fastq/bam compression, than this thread?
    Discussion of next-gen sequencing related bioinformatics: resources, algorithms, open source efforts, etc


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