Solid vs Illumina Genome Analyzer

pinki999

Member

Join Date: Oct 2010

Posts: 37
- Share
- Tweet
#1

Solid vs Illumina Genome Analyzer

10-06-2010, 06:52 AM

Hello Friends,

I am supposed to decide on whether to opt for Solid or Illumina GA for my project (transcriptome analysis). Can you guys throw some light on advantages and disadvantages of both the technologies and also the cost per run.

Regards,
Pinki

Last edited by pinki999; 10-07-2010, 12:16 AM.
Tags: illumina ga, solid
westerman

Rick Westerman

Join Date: Jun 2008

Posts: 1104
- Share
- Tweet
#2

10-06-2010, 07:34 AM

It would be nice to know what your project is so that we can be more specific in any recommendations.

Basically the SOLiD has more reads of shorter length than the GA. This may or may not be appropriate for your project. It mainly depends on if you are detecting variants (SNPs, InDels) or trying to do more de-novo assembly work. Repetitiveness of the organism is a factor.

The cost per full run (or plate) is close to the same -- at least within a factor of 2. You will probably find that post-processing informatics will mask any differential in cost. Not all projects require full plates; e.g., re-sequencing E.coli can easily be done on a partial plate.
Comment

Previous template Next

Advanced Sequencing Platforms Tackle Neuroscience’s Toughest Genomics Problems

by SEQadmin2

Genomics studies in neuroscience face a special challenge due to the brain’s complexity and scarcity of samples. Mapping changes in cell type and state using conventional next-generation sequencing methods remains challenging. Advances in technologies like single-cell sequencing, spatial transcriptomics, and long-read sequencing have opened the door to deeper studies of the brain and diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and schizophrenia.
...
- Channel: Articles
07-09-2026, 11:10 AM
Cancer Drug Resistance: The Lingering Barrier to Rising Survival

by SEQadmin2

Cancer survival rates have significantly increased in the last few decades in the United States, reaching a combined 70% 5-year survival rate by 2021. Behind this number, there are years of research to find new therapies, drug targets, and early detection methods. But there is one core challenge that keeps slowing down these advances, and it’s about drug resistance.

There is no single reason why many patients don’t respond to treatment as expected. Cancer is...
- Channel: Articles
07-08-2026, 05:17 AM
Reply to Nine Things a Sample Prep Scientist Thinks About Before Sequencing

by GATTACAT

Love this - good data definitely starts from good input, and poor input can only give relatively poor data. I particularly like the mention of Nanodrop/absorbance based methods for quantification. It's such a toss up if you'll get an accurate reading or what amounts to a randomly generated number, and a lot of library/sequencing related issues can be traced back to poor quant.
- Channel: Articles
07-01-2026, 11:43 AM

Topics	Statistics	Last Post
UC San Diego Bioengineers Map Gene Function in Human Stem Cells by SEQadmin2 Started by SEQadmin2, Yesterday, 10:26 AM	0 responses 13 views 0 reactions	Last Post by SEQadmin2 Yesterday, 10:26 AM
New Analysis Splits Leukemia Into 16 Epigenomic Subgroups by SEQadmin2 Started by SEQadmin2, 07-09-2026, 10:04 AM	0 responses 26 views 0 reactions	Last Post by SEQadmin2 07-09-2026, 10:04 AM
Genome-Wide CRISPR Screen Uncovers Unlikely Psoriasis Target by SEQadmin2 Started by SEQadmin2, 07-08-2026, 10:08 AM	0 responses 16 views 0 reactions	Last Post by SEQadmin2 07-08-2026, 10:08 AM
Engineered Protein Motor Takes Its First Steps Along DNA Track by SEQadmin2 Started by SEQadmin2, 07-07-2026, 11:05 AM	0 responses 33 views 0 reactions	Last Post by SEQadmin2 07-07-2026, 11:05 AM

Unconfigured Ad

Solid vs Illumina Genome Analyzer

Comment

Latest Articles

ad_right_rmr

News