GC bias in Solid system?

[yamayaya]

Does anybody know the GC bias problem when using solid system for more complicated genome sequencing. e.g. mammal?

Is there any published paper talking about the substantial bias caused by GC content?

Many thank~!

[nilshomer]

Does anybody know the GC bias problem when using solid system for more complicated genome sequencing. e.g. mammal?

Is there any published paper talking about the substantial bias caused by GC content?

Many thank~!

I have analyzed GC bias on both SOLiD and Illumina for Human samples. While there is a bias, they both are comparable. PM me if you want some figures etc.

[NextGenSeq]

By Covarising (if that's a word) at 2-5C ABI claims they eliminate GC bias.