Any ABI-recommended programs for read-trimming? I understand it might not be necessary due to the nature of BioScope's mapping software. Thank you.
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No need for read trimming. -
but you my need to use masks...Comment
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We doubled our mapping by trimming all reads > 35b to 35b
Please see thread in the Bioinformatics forum.
best,
jlwComment
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You can look at quality values of the reads. If you see drastic drop down in quality values at the end of every reads , you can trim reads by several bases....which should increase mapping... If you use corona_lite for mapping there is an option of masking several positions during mapping...
Bioscope mapping is seed based , so even if you dont trim , reads will still map the reference...Comment
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The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.
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